Influenza (flu) is a universally common epidemic illness caused by several subtypes of type A or by type B influenza virus. (Type C influenza virus exists and produces a mild respiratory illness but is not believed to cause epidemics.) The most common subtypes of influenza A are H1N1 and H3N2. A swine-origin influenza A (H1N1) virus outbreak in 2009 reinforced that interspecies transmission of human and animal influenza A viruses and subsequent reassortment are possible and occur, resulting in new viruses that may spread to humans and even easily between humans. Human infections with variant influenza viruses most commonly happen in people with exposure to infected pigs. A subtype of avian influenza A that emerged in Asia (H5N1) historically produced infrequent but often fatal human illness. In 2024, human cases of H5N1 have been linked to outbreaks among US dairy cows and poultry.

Current flu season: Per the Centers for Disease Control and Prevention (CDC), as of November 23, 2024, seasonal influenza activity is increasing slightly among children but remains low nationally.

Coinfection with influenza A or B viruses, respiratory syncytial virus, and SARS-CoV-2 can occur.

Influenza is highly contagious and is spread by aerosol droplets. The incubation period is 1-4 days, but it becomes contagious 1 day prior to the onset of symptoms. The mortality rate of influenza is low but tends to be higher in older adults and individuals who are immunocompromised. Flu activity usually peaks in February.

Influenza presents with classic flu-like illness consisting of the sudden onset of fever, malaise, sore throat, nonproductive cough, myalgias, headache, and nasal congestion. Chills are common, as are nausea and vomiting in children. After 48 hours, cough may increase and produce sputum. There may be associated dyspnea and/or mild-to-moderate pleuritic chest pain. Upon physical examination, unilateral or bilateral inspiratory rales may be appreciated or diminished breath sounds. Pregnant individuals are at increased risk for severe illness from influenza.

Most viruses that affect the respiratory tract can cause a rash, flu included (see viral exanthem).

The most common pulmonary complication of influenza is secondary bacterial pneumonia. This diagnosis can be determined by patient history. This can occur up to 2 weeks after the initial symptoms and includes recurrence of fever, chills, pleuritic chest pain, and productive cough. Many bacteria may be the culprit, but the most common are pneumococci. Staphylococcus aureus has also been implicated in children; there has been an increase in the number of deaths in which both influenza and pneumonia or bacteremia due to S aureus were identified.

Primary viral pneumonia is the complication responsible for the most influenza-related deaths. Those with pre-existing cardiopulmonary disease or who are pregnant are at the greatest risk. The initial clinical presentation is the same, but dyspnea increases in severity. Productive cough may be blood tinged. Massive hemoptysis has been reported. When severe, there may be profound respiratory distress with tachypnea, tachycardia, and cyanosis. Rales and wheezes will spread throughout the chest from the lower lung.

The Spanish flu pandemic of 1918 was particularly virulent, killing over 20 million people worldwide.

Note: In 2022 and 2023, pediatric invasive group A streptococcal (iGAS) infections and noninvasive group A streptococcal infection cases were associated with respiratory infections due to influenza, among other viruses. Concurrent or preceding viral infections, including varicella (chickenpox), may increase risk for iGAS infection. Severe outcomes of iGAS infections include necrotizing fasciitis, streptococcal toxic shock syndrome, and death.