Stargardt disease
Alerts and Notices
Important News & Links
Synopsis
![Stargardt disease : Blurred vision, Macula abnormality, Vision loss](/visualdx/sympticonswm/2188.png?r=1fdb69a28)
Stargardt disease is a hereditary disorder of macular degeneration due to mutations in the ABCA4 (autosomal recessive pattern) or ELOVL4 (autosomal dominant pattern) genes. The most common type of juvenile macular degeneration. As a result of the build-up of toxic substances in photoreceptor cells due to ABCA4 mutation, retinal cell death occurs and central vision progressively worsens. Long-chain fatty acid ELOVL4 aggregate build-up impairs cell function and causes retinal cell death, contributing to progressive vision loss. Onset in children ages 7-12. No curative therapy is available, although gene replacement therapy is in development. Avoiding overexposure to light and avoiding vitamin A supplements may help delay progression.
Codes
ICD10CM:
H35.50 – Unspecified hereditary retinal dystrophy
SNOMEDCT:
70099003 – Stargardt's disease
H35.50 – Unspecified hereditary retinal dystrophy
SNOMEDCT:
70099003 – Stargardt's disease
Differential Diagnosis & Pitfalls
To perform a comparison, select diagnoses from the classic differential
Subscription Required
Best Tests
Subscription Required
References
Subscription Required
Last Updated:01/24/2022