Angiokeratomas of the scrotum (Fordyce angiokeratomas) are benign, often asymptomatic, 2-5 mm, warty or smooth-topped, red-to-violaceous papules composed of dilated dermal capillaries. The pathophysiology is unknown, but it is speculated that they may be caused by increased venous pressure due to their occasional association with vascular conditions such as varicoceles. The lesions may bleed spontaneously or with slight trauma, which is often distressing to patients.

The condition is more common in men. However, angiokeratomas may also be seen on the inner thighs, lower abdomen, and on the vulva in women (angiokeratoma of vulva). Prevalence data indicates that the condition is more common in individuals of Northern European and Japanese descent, and that incidence increases with advancing age.