Angioleiomyoma (AL) is a variant of leiomyoma that is characterized histopathologically by the presence of vascular channels as well as smooth muscle bundles. It is thought to arise from vascular smooth muscle cells. It typically presents as a single, slowly enlarging papule or nodule on the leg of a middle-aged woman. However, men are also affected and pediatric cases have been reported. ALs have been reported on the trunk, face, and upper extremities too.

While lower extremity ALs are reported to be painful, those that occur elsewhere on the body are usually asymptomatic. Pain may be spontaneous and paroxysmal or may be precipitated by light touch or pressure.