Staphylococcal scalded skin syndrome (SSSS), or Ritter disease, is an acute disease caused by epidermolytic toxins released by strains of Staphylococcus aureus. Any systemic or cutaneous infection with epidermolytic toxin producing S. aureus may induce SSSS. Oftentimes, it is a focal infection of the nasopharynx, conjunctivae, perineum, or umbilicus that produces toxins that lead to diffuse fragile bullae, which are often no longer intact at the time of presentation. Children younger than 6 are believed to have increased susceptibility to SSSS due to decreased renal ability to excrete the toxin. The severity ranges from limited cutaneous involvement to diffuse skin disease and sepsis.