Contents

SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences
Acquired pancytopenia in Adult
Other Resources UpToDate PubMed

Acquired pancytopenia in Adult

Contributors: Nina Haghi MD, Benjamin L. Mazer MD, MBA, Carla Casulo MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Pancytopenia is a decrease in all 3 peripheral blood lineages presenting as simultaneous anemia, leukopenia, and thrombocytopenia.

Acquired pancytopenia has many etiologies, but it is broadly grouped into 1 of 3 mechanisms causing decreased blood cell counts: bone marrow infiltration / replacement, bone marrow aplasia, or blood cell destruction or sequestration. Multiple mechanisms may occur simultaneously.

Bone marrow infiltration / replacement may be secondary to hematologic malignancy (such as lymphoma, myeloma, leukemia, myelodysplastic syndrome), myelofibrosis, metastatic disease, and infectious processes (tuberculous, fungal infection, etc). Bone marrow aplasia may be due to nutritional deficiencies, viral infection, immune destruction, drug effect, toxic exposures, or aplastic anemia. Blood cell destruction may occur due to ineffective hematopoiesis (ie, myelodysplastic syndrome), disseminated intravascular coagulation, or thrombotic thrombocytopenic purpura. Hypersplenism causes sequestration and is associated with various disease states (cirrhosis, lymphoma, autoimmune disorders, etc).

Codes

ICD10CM:
D61.818 – Other pancytopenia

SNOMEDCT:
5876000 – Acquired pancytopenia

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

Subscription Required

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Subscription Required

References

Subscription Required

Last Reviewed:08/13/2019
Last Updated:08/13/2019
Copyright © 2024 VisualDx®. All rights reserved.
Acquired pancytopenia in Adult
Captions Print  
A medical illustration showing key findings of Acquired pancytopenia : Fatigue, Bleeding time prolonged, Pancytopenia, Asthenia, Pallor, WBC decreased, PLT decreased, RBC decreased
Clinical image of Acquired pancytopenia - imageId=1552640. Click to open in gallery.  caption: 'Widespread purpuric patches and petechiae on the trunk and arms.'
Widespread purpuric patches and petechiae on the trunk and arms.
Copyright © 2024 VisualDx®. All rights reserved.