Ofuji disease, or classic eosinophilic pustular folliculitis (EPF), is an inflammatory folliculitis characterized by sterile follicular pustule formation.

Classical EPF is more common in immunocompetent individuals in Japan and has a slight male predominance with peak incidence around the age of 30. Recurrent crops of follicular papular pustules arise on normal skin and atop erythematous plaques. There is typically intense accompanying pruritus. The lesions often heal in 7-10 days and reappear every 3-4 weeks. The face and trunk are commonly affected, but other variants can affect the extremities, palms, and soles. Systemic symptoms are not usually seen.

The etiology of classic EPF remains unclear. Some evidence suggests involvement of cytokines and adhesion molecules that activate the follicular unit.