Glioblastoma multiforme is the most common primary malignant brain tumor in adults. This glial tumor is aggressive and grows quickly, invading surrounding brain tissue. Patients may present with severe persistent headaches, nausea / vomiting, seizures, memory or language impairment, or personality changes. There may also be focal deficits, such as hemiparesis, depending on the location of the tumor. Age of onset is usually 45-70 years old.

Prognosis is poor, and median survival is about 15-18 months with treatment and 3-5 months without treatment.