Pulmonary amyloidosis is the manifestation of sarcoidosis, an infiltrative disease process that can present in several organs, in the respiratory tract. Amyloidosis of the lungs frequently has either peripheral or subpleural pulmonary nodules or thickening of the tracheal or bronchial walls. It rarely causes pulmonary hypertension. Depending on the location of amyloid deposits, pulmonary amyloidosis is characterized as tracheobronchial, nodular parenchymal, or diffuse septal amyloidosis.

Signs and symptoms include cough, dyspnea, wheezing, hemoptysis, increased respiratory rate, pleural effusions, and multiple pulmonary nodules or masses. Pulmonary interstitial amyloidosis is symptomatic if amyloid deposits affect gas exchange. Tracheobronchial amyloidosis can cause airway stenosis, and local parenchymal involvement can present as nodular amyloidosis.