A rare autosomal dominant, multi-faceted genetic syndrome attributed to mutations in CHD7 protein. Key features of CHARGE syndrome are represented by its pneumonic name and include: Coloboma, Heart anomalies, choanal Atresia, Retardation of growth and development, and Genital and Ear anomalies. CHARGE syndrome in newborns may be life-threatening, as it presents with feeding difficulties, heart defects, and airway obstruction. Other common signs and symptoms include sensory loss, cleft palate, and other facial and limb anomalies, and in males, hypogonadotropic hypogonadism.