Progressive supranuclear palsy is a neurodegenerative disorder caused by destruction of brain cells, primarily in the brain stem, and accumulation of tau protein. Average age of onset is 60-65 years, and it is more common in men. Symptoms include parkinsonism (bradykinesia, rigidity, with or without tremor), axial rigidity, gait / postural instability and early falls, eye movement abnormalities, blurry vision, blepharospasm, eyelid opening apraxia, dysarthria, dysphagia, retrocollis, cognitive decline, depression, anxiety, apathy, behavioral changes, and pseudobulbar palsy.

Lack of response to levodopa is common. Prognosis is poor; most patients are significantly disabled within 5 years of diagnosis and die within 10 years of diagnosis.