Mantle cell lymphoma (MCL) is a mature B-cell lymphoma that can present with lymphadenopathy, peripheral blood involvement, and/or extranodal involvement. MCL can involve any portion of the gastrointestinal system and may present as lymphomatous intestinal polyposis. It is often a very aggressive disease.

It is characterized by a CCND1 translocation, t(11;14)(q13;q32), in more than 95% of cases.

MCL makes up 3%-10% of non-Hodgkin lymphomas and occurs in older individuals (median age of 60-70 years) with a male predominance. Most patients present with advanced (stage III or IV) disease. Symptoms may include fatigue, fever, night sweats, unintentional weight loss, lymphadenopathy, hepatosplenomegaly, and/or abdominal discomfort.