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SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences
Cocaine mucosal ulcer - Oral Mucosal Lesion
Other Resources UpToDate PubMed

Cocaine mucosal ulcer - Oral Mucosal Lesion

Contributors: Vivian Wong MD, PhD, Susan Burgin MD, Carl Allen DDS, MSD, Sook-Bin Woo MS, DMD, MMSc
Other Resources UpToDate PubMed

Synopsis

Cocaine use is associated with mucosal disease with subsequent painful ulcerations. As cocaine is absorbed through the mucosal membrane, it produces vasoconstriction, anesthesia, and local ischemic necrosis of the mucosal tissue (and sometimes the cartilage and bone). The pathology can occur in multiple organ systems, including the ocular, nasal, oral, and gastrointestinal systems, with serious sequelae such as perforations, fistula, and stricture formation. Agranulocytosis, which can occur secondary to cocaine (and the additive levamisole), contributes to superinfections.

Related topic: cocaine intoxication and use disorder, cocaine levamisole toxicity

Codes

ICD10CM:
T40.5X5A – Adverse effect of cocaine, initial encounter

SNOMEDCT:
403665005 – Drug-induced oral ulceration

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

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Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

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References

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Last Updated:06/16/2024
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Cocaine mucosal ulcer - Oral Mucosal Lesion
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A medical illustration showing key findings of Cocaine mucosal ulcer : Cocaine use
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