Eosinophilic dermatosis of hematologic malignancy (EDHM), also known as insect bite-like persistent hypersensitivity reaction, is a rare eosinophilic eruption associated with hematoproliferative diseases. Clinical presentations vary, ranging from erythematous or urticarial papules, plaques, or nodules, to vesicles and bullae. Lesions have a tendency to persist over long periods and recur, and they may be accompanied by significant pruritus.

Although clinical and histological features simulate insect bites, the condition is currently regarded as a paraneoplastic cutaneous reaction pattern likely mediated by interleukin (IL)-4 and IL-5.

EDHM is most commonly associated with chronic lymphocytic leukemia, affecting up to 7% of patients in some studies. It has also been reported in patients with myelofibrosis, acute myelomonocytic leukemia, acute lymphocytic leukemia, mantle cell lymphoma, large cell lymphoma, and myeloma. EDHM can precede, occur concurrently, or appear after the cancer diagnosis. EDHM is a disease of adults. The youngest reported patient with EDHM was 21 years of age.