Contents

SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences
Eruptive squamous atypia
Other Resources UpToDate PubMed

Eruptive squamous atypia

Contributors: Casey P. Schukow DO, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Eruptive squamous atypia (ESA) is a distinct entity characterized by the presence of one or more scaly or crusted papules, plaques, or nodules that display a proliferation of well-differentiated, atypical keratinocytes on histopathology. ESA is also commonly referred to as eruptive keratoacanthoma (eruptive KA). However, this term is a misnomer as "keratoacanthoma" implies squamous cell carcinoma (SCC), whereas ESA represents reactive squamous proliferation.

ESA can be subcategorized into 2 morphologic types. The first type is focal koebnerizing ESA (FK-ESA), which appears as a hyperkeratotic papule or plaque that arises in areas of localized skin trauma, such as surgery, laser therapy, or tattoo application. The second type is diffuse ESA (D-ESA), which presents as multifocal ESA lesions, often on the arms or legs.

Both patterns may occur simultaneously. A skin biopsy should be used to confirm the diagnosis.

Codes

ICD10CM:
L85.8 – Other specified epidermal thickening

SNOMEDCT:
69740004 – Squamous cell atypia

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

To perform a comparison, select diagnoses from the classic differential

Subscription Required

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Subscription Required

References

Subscription Required

Last Reviewed:02/13/2022
Last Updated:02/13/2022
Copyright © 2024 VisualDx®. All rights reserved.
Eruptive squamous atypia
Print  
A medical illustration showing key findings of Eruptive squamous atypia : Dorsum of hand, Erythema, Lower leg, Scaly papule/plaque
Copyright © 2024 VisualDx®. All rights reserved.