Sticky skin (acquired cutaneous adherence) is an adverse drug reaction associated with systemic retinoids, doxorubicin / ketoconazole combination therapy, and proton-pump inhibitors (lansoprazole and esomeprazole). The entire skin is affected, but stickiness is most exaggerated on the acral surfaces. Patients report a sticky sensation and a tendency for objects to adhere to the skin. The symptoms may be dose-dependent and respond to decreased dose or withdrawal of medication. While the pathomechanism is unknown, stratum corneum adherence to increased levels of glycoprotein in sweat has been postulated.