Nodular scleritis is one of the more commonly encountered forms of scleritis. Nodular scleritis is an inflammatory condition affecting the sclera that is often associated with underlying systemic collagen vascular disease, vasculitis, or other auto-immune disease. Nodular scleritis causes severe injection and pain in an elevated area (or nodule) of sclera. It is most commonly seen in middle-aged women. Approximately one third of patients with nodular scleritis have an underlying systemic condition that will cause both eyes to be affected, though sometimes asymmetrically. The scleral inflammation can affect adjacent tissues and, many times, the peripheral cornea can become involved, causing visual loss.